Les chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert une nouvelle approche pour cibler les cellules canc\u00e9reuses.<\/strong><\/em><\/p>\n

Des chercheurs de l’Universit\u00e9 de Tel Aviv (TAU) ont d\u00e9couvert que le nombre anormal de chromosomes dans les cellules canc\u00e9reuses pourrait s’av\u00e9rer \u00eatre le \u00abtalon d’Achille\u00bb de la maladie, ouvrant la voie \u00e0 de futurs m\u00e9dicaments pour attaquer le nouveau point faible.<\/p>\n

Alors que les chercheurs connaissent depuis des d\u00e9cennies le nombre anormal de chromosomes des cellules canc\u00e9reuses, une caract\u00e9ristique unique connue sous le nom d ‘\u00abaneuplo\u00efdie\u00bb, leur compr\u00e9hension de la fa\u00e7on dont l’aneuplo\u00efdie contribue au d\u00e9veloppement et \u00e0 la propagation du cancer est limit\u00e9e.<\/p>\n

Les chercheurs de TAU ont d\u00e9couvert le point critique auquel les cellules aneuplo\u00efdes canc\u00e9reuses sont sensibles aux dommages (le point de contr\u00f4le mitotique) et la raison d’une sensibilit\u00e9 accrue \u00e0 cet endroit.<\/p>\n

Les m\u00e9dicaments ciblant ce m\u00e9canisme pourraient repr\u00e9senter des perc\u00e9es majeures dans la m\u00e9decine personnalis\u00e9e du cancer.<\/p>\n

Les r\u00e9sultats de l’\u00e9tude men\u00e9e par TAU sugg\u00e8rent qu’il sera possible d’utiliser l’aneuplo\u00efdie comme marqueur biologique pour identifier les patients qui r\u00e9pondraient mieux \u00e0 des m\u00e9dicaments sp\u00e9cifiques.<\/p>\n

L’\u00e9tude de la facult\u00e9 de m\u00e9decine Sackler de la TAU a \u00e9t\u00e9 r\u00e9alis\u00e9e en collaboration avec six autres laboratoires dans quatre autres pays et a \u00e9t\u00e9 publi\u00e9e la semaine derni\u00e8re dans la prestigieuse revue \u00e0 comit\u00e9 de lecture Nature.<\/p>\n

Selon le Dr Uri Ben-David, l’aneuplo\u00efdie est le changement g\u00e9n\u00e9tique le plus courant dans le cancer. Environ 90% des tumeurs solides, telles que le cancer du sein et le cancer du c\u00f4lon, et 75% des cancers du sang sont de nature aneuplo\u00efde.<\/p>\n

\u00abIl convient de souligner que l’\u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e sur des cellules en culture et non sur des patients canc\u00e9reux<\/em>\u00bb, a d\u00e9clar\u00e9 le Dr Ben-David. \u00ab\u00a0Afin de le traduire en traitement des patients canc\u00e9reux, de nombreuses autres \u00e9tudes de suivi doivent \u00eatre effectu\u00e9es. Pourtant, m\u00eame \u00e0 ce stade, il est clair que l’\u00e9tude pourrait avoir un certain nombre d’implications m\u00e9dicales.<\/em>\u00ab\u00a0<\/p>\n

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Les chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert une nouvelle approche pour cibler les cellules canc\u00e9reuses. Par Yakir Benzion, Unis avec Isra\u00ebl Des chercheurs de l’Universit\u00e9 de Tel Aviv (TAU) ont d\u00e9couvert que le nombre anormal de chromosomes dans les cellules canc\u00e9reuses pourrait s’av\u00e9rer \u00eatre le \u00abtalon d’Achille\u00bb de la maladie, ouvrant la voie… Read more 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