Israeli researchers develop method to diagnose diabetes, multiple sclerosis, pancreatic cancer, pancreatitis and brain damage from one blood test.
An Israeli-led international team of researchers has proof of concept for a single blood test that can detect multiple conditions, including diabetes, cancer, traumatic injury and neurodegeneration, in a highly sensitive and specific manner.
The novel method, tested on 320 patients and control groups, zeroes in on patterns of circulating DNA that is released by dying cells and traces it to specific types of tissue.
The study was reported in a paper published recently in the journal Proceedings of National Academy of Sciences USA.
Cell death can signify the early stages of pathology (such as a developing tumor or the beginning of an autoimmune or neurodegenerative disease), mark disease progression, reflect the success of therapy (such as anti-cancer drugs), identify unintended toxic effects of treatment and more.
However, until now it was not possible to measure cell death in specific human tissues noninvasively.
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