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Hearing
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Tel Aviv U scientists discover new pathway for treating hearing loss; Technion decodes genome causing of sleeping sickness; Israeli-founded Irish-Israeli startup develops minimally invasive solution for acute decompensated heart failure; and much more!

By Michael Ordman

ISRAEL’S MEDICAL ACHIEVEMENTS

New pathway for treating loss of hearing

Tel Aviv University scientists have produced the world’s first map of “methylation” (natural gene manipulation) that impacts development and ultimately loss of function of the entire inner ear. They have revealed many new genes that may help restore hearing to deaf children and adults.
https://www.aftau.org/weblog-medicine–health?&storyid4704=2424&ncs4704=3 http://kbalab.com/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255903/

New treatment for heart failure

Israeli-founded Irish-Israeli startup Whiteswell has developed a minimally invasive solution for acute decompensated heart failure (ADHF). It involves a catheter to drain excess fluid. Whiteswell has just raised $30 million of funds to support development and trials.
https://en.globes.co.il/en/article-heart-failure-treatment-co-whiteswell-raises-30m-1001264383
http://whiteswell.com/

Sleeping sickness parasite genome decoded

Dr. Noam Kaplan of Israel’s Technion Institute is a member of an International team of scientists that has decoded the genome of the fatal parasite Trypanosoma brucei – the cause of human “sleeping sickness”. It should help in the development of techniques to block the fatal disease.
https://www.technion.ac.il/en/home-2/#/hazardous-sleep/%20#content

Going bats to understand spatial awareness

Researchers at Israel’s Weizmann Institute have found that humans are more like bats than rats in how our brains help us navigate the environment. Rat neurons only emit predictable. rhythmic oscillations, whereas bats and primates additionally use far more complex mechanisms.
https://wis-wander.weizmann.ac.il/life-sciences/bat-brains-forgo-rhythm-when-encoding-space

FDA designation for solid tumor treatment

I reported previously (28 Jan) that the AGI-134 solid tumor treatment from Israel’s BiolineRX showed promise. The U.S. FDA has just granted Biological Product Designation for the novel immunotherapy compound. Early trials show complete regression of tumors.
https://www.prnewswire.com/news-releases/biolinerx-announces-receipt-of-fda-biological-product-designation-for-novel-cancer-immunotherapy-candidate-agi-134-300753579.html

Restoring the digestive system

Israel’s E-Motion Medical has just received the CE Mark (i.e. European approval) for its E-Motion System, providing stimulation therapy that restores the natural motor function of the digestive system for patients with acute gastrointestinal dysmotility (GID).
https://www.prnewswire.com/news-releases/e-motion-medical-receives-ce-mark-approval-for-its-novel-stimulation-therapy-for-patients-with-acute-digestive-dysmotility-300753556.html  http://emotionmed.com/

New program for treating eating disorders

Haifa’s Rambam Medical Center has set up a new daily program to treat young people up to age 30 in Northern Israel with eating disorders. Each patient receives an intensive, personized plan plus access to doctors, nurses, psychiatrists, psychologists, dieticians and social workers.
https://www.rambam.org.il/en/rambam_news/New_eating_disorders_treatment.aspx

Gut microbiome-analysis startup’s $5 million lab

I wrote previously (19th Aug) that Israeli startup DayTwo will provide members of health care provider Clalit with personalized nutrition plans based on DNA analysis of gut microbiome. DayTwo is now setting up a $5 million lab in Rehovot, working with the Weizmann Institute.
https://www.calcalistech.com/ctech/articles/0,7340,L-3751336,00.html

Of mice and men

Israeli biotech CytoReason and Israel’s Technion Institute are analyzing the immune system at the cell level. As a result, they have just published a groundbreaking new mouse to human model. It will help scientists develop treatments faster that work both in clinical and human trials. Great video.
https://medkit.info/2018/06/19/cytoreason-builds-largest-reference-of-immune-focused-inter-cellular-communications/ http://www.cytoreason.com/https://www.youtube.com/watch?v=GjmJzS7_QN4

Patient motoring guidance system

I reported previously (Dec 2011) that the universities of Haifa and Ben Gurion were building MobiGuide to monitor patients outside clinically controlled environments. MobiGuide is now the first AI system for the automated management of atrial fibrillation and gestational diabetes patients.

https://moh-it.pure.elsevier.com/en/publications/mobiguide-a-personalized-and-patient-centric-decision-support-sys

https://aabgu.org/bgu-innovation-mobiguide/

See the new migraine relief device. I reported previously (21st May) that Israel’s Neurolief was developing a non-invasive brain neuro-modulation interface system that could relieve migraine headaches. This Israel21c article shows the device, describes the technology and plans. The device is also in trials to treat depression.
https://www.israel21c.org/migraine-relief-from-an-israeli-neuro-modulation-device/

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